RESPONSIVENESS OF GERMFREE MICE IN MIXED LEUKOCYTE CULTURE
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چکیده
منابع مشابه
Responsiveness of Germfree Mice in Mixed Leukocyte Culture
Conventional (cv) and germfree (gf) mice are able to give a good proliferative response to allogeneic cells in the mixed leukocyte culture (MLC) test, while the response to xenogeneic stimulating cells has been in question. Previous studies by others have suggested only a low MLC response in cv animals and none in gf ones. We have found that both cv and gf animals can give a good MLC response t...
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The reactivity of lymphoid cells from germfree and conventional CDF rats were compared in mixed leukocyte culture (MLC) with both allogeneic rat leukocytes and with human leukocytes as stimulating cells, and in a graft-versus-host (GVH) assay. There was no difference between germfree and conventional rats in any of these systems. Furthermore, the increase in GVH activity after specific immuniza...
متن کاملGenetic and cellular aspects of xenogeneic mixed leukocyte culture reaction
The nature of the antigens stimulating xenogeneic lymphocytes was studied using "primed LD typing". Human lymphocytes were sensitized in vitro against mouse spleen cells and restimulated with spleen cells of mouse strains sharing non-H-2 antigens or various regions of H-2 with the initial stimulating strain. The largest thymidine uptake was caused by restimulation with cells from the specific p...
متن کاملMixed Lymphocyte Culture Responses of Mice
Cellular responses in vitro to H-2D region histocompatibility antigens were demonstrated to be under the genetic control of two or three (P = 0.013) independently segregating loci. The H-2 region itself accounts for one of these loci, however, its activity appears to be dependent upon an association with other non-H-2-associated genetic information. The ability to stimulate a response and to re...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1972
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.136.2.398